Lack of sleep can lead the brain to begin destroying its own healthy connections, according to new research published in the Journal of Neuroscience. According to researchers, this occurs when brain cells called astrocytes and microglia, which are in charge of removing superfluous neuronal connections, are overactive.
Through the use of mouse models, scientists discovered that persistent sleep disruption causes these cells to become hyperactive, which in turn causes an excessive pruning of synapses—the crucial connections between brain cells. Although synaptic pruning is a natural process that aids in brain function, an excess of it brought on by sleep deprivation may be more detrimental than beneficial.
Scientists are now worried that chronic sleep deprivation may increase the brain’s susceptibility to neurodegenerative illnesses like Alzheimer’s and cognitive decline. This is due to the possibility that excessive pruning could harm critical neuronal networks that are necessary for concentration, memory, and general brain function.
Curiously, other research indicates that astrocytes, a different kind of brain cell, may react differently to sleep deprivation than microglia, which cause them to become hyperactive. To completely comprehend the depth of sleep deprivation’s effects on the brain, scientists say additional research is necessary.
Researchers’ message is clear for the time being: Getting enough sleep is essential for maintaining brain function and isn’t only about feeling rested. If you’re not getting enough sleep, it may be time to reconsider your routine before your brain begins to oversimplify.
